Texto retirado da página: http://www.sciencedaily.com/releases/2015/06/150622162023.htm
"Molecular mechanisms within fetal lungs initiate labor
Date:June 22, 2015
Source:UT Southwestern Medical
CenterSummary: Researchers have identified two proteins in a fetus' lungs responsible for initiating the labor process, providing potential new targets for preventing preterm birth. They discovered that the proteins SRC-1 and SRC-2 activate genes inside the fetus' lungs near full term, leading to an inflammatory response in the mother's uterus that initiates labor.
Researchers at UT Southwestern Medical Center have identified two proteins in a fetus' lungs responsible for initiating the labor process, providing potential new targets for preventing preterm birth.
Previous studies have suggested that signals from the fetus initiate the birth process, but the precise molecular mechanisms that lead to labor remained unclear. UT Southwestern biochemists studying mouse models found that the two proteins − steroid receptor coactivators 1 and 2 (SRC-1 and SRC-2) -- control genes for pulmonary surfactant components that promote the initiation of labor. Surfactant is a substance released from the fetus' lungs just prior to birth that is essential for normal breathing outside the womb.
"Our study provides compelling evidence that the fetus regulates the timing of its birth, and that this control occurs after these two gene regulatory proteins − SRC-1 and SRC-2 − increase the production of surfactant components, surfactant protein A and platelet activating factor," said senior author Dr. Carole Mendelson, Professor of Biochemistry, and Obstetrics and Gynecology at UT Southwestern.
"By understanding the factors and pathways that initiate normal-term labor at 40 weeks, we can gain more insight into how to prevent preterm labor," said Dr. Mendelson, Director of the North Texas March of Dimes Birth Defects Center at UT Southwestern.
Each year about one in every nine infants in the United States is born preterm (before 37 weeks), according to the Centers for Disease Control and Prevention. Premature birth can cause brain hemorrhage and respiratory distress for babies, as well as long-term conditions such as cerebral palsy, chronic lung disease, and impaired vision.
The study, which appears in the Journal of Clinical Investigation, was supported by the National Institutes of Health and a Prematurity Research Initiative grant from the March of Dimes Foundation.
UT Southwestern researchers found that the proteins SRC-1 and SRC-2 activate genes inside the fetus' lungs near full term, resulting in an increased production of surfactant components, surfactant protein A (SP-A), and platelet-activating factor (PAF). Both SP-A and PAF are then secreted by the fetus' lungs into the amniotic fluid, leading to an inflammatory response in the mother's uterus that initiates labor.
The current study showed that a deficiency of both SRC-1 and SRC-2 inside the fetus' lungs drastically decreased the production of SP-A and PAF, causing a one- to two-day labor delay in mouse models, comparable to a three- to four-week labor delay in women.
Researchers further found that injecting either SP-A or PAF into the amniotic fluid of the deficient mice allowed the mothers to deliver on time. Together, the findings further define the underlying molecular mechanisms by which fetuses control the timing of birth.
Future research will include defining how fetal signals are transmitted to the mother's uterus, and relating these findings to the causes of preterm labor.
The study was conducted with current and former UT Southwestern researchers, including first author Dr. Lu Gao; Dr. Elizabeth Rabbitt; Dr. Jennifer Condon; Dr. Nora Renthal; Dr. John Johnston; Dr. Matthew Mitsche; and researchers from the Institut de Génétique et de Biologie Moléculaire et Cellulaire, France, and Baylor College of Medicine in Houston.
The above post is reprinted from materials provided by UT Southwestern Medical Center. Note: Materials may be edited for content and length.
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Texto retirado da página do Dr. Christopher Stroud
"Birth is exciting. This comes as no surprise to anyone who follows this page. Birth is always exciting. Witnessing the arrival of an infant, particularly in the natural manner in which it was masterfully designed, simply never gets old. But today Lindsay, Dr. Martin, and I had a uniquely exciting experience, as we were fortunate to participate in the natural birth of triplets.
We met Martha about six weeks ago. She was referred to us by a friend in hopes of finding providers that would help her achieve a natural birth instead of cesarean section for her triplets. I think we were just as happy to meet Martha, as she was to meet us. She wanted a vaginal birth for her babies and we wanted to help her achieve it.
From the moment I mentioned the idea to the leadership team at DuPont Hospital they were completely supportive. They immediately began making arrangements to assure we would have all we needed. We needed extra nurses in labor and delivery, extra nurses from the neonatal intensive care unit, extra equipment in case of an emergency—there was much to be done in preparation for this event. The hospital could have said, “No, this is too complicated, have them go to another facility,” but they didn’t. A group of nurses volunteered to come in for her birth even if they weren’t scheduled to work in hopes of helping her achieve her goal. They responded with everything we needed to provide excellent care to Martha and her babies.
And so today, just after 4:00 PM these beautiful babies were born. The first baby born was Loren, a 5 pound, 11 ounce boy. Just a few minutes later his sister, Leanne was born weighing 4 pounds, 9 ounces. Finally, 23 minutes after her older sister was born, Lori entered the world feet-first, weighing 4 pounds, 9 ounces.
I’ve witnessed many beautiful births in my 20 years as a physician, but none more exciting than today’s. My sincere thanks to DuPont Hospital and it’s wonderful team of professionals for providing such great care to my patient, to my new partner Dr. Angela Martin and our amazing Nurse-Midwife Lindsay Davidson for their support, and of course, to Martha and her husband for trusting us to play a part in their pregnancy journey. God’s blessings this night to Loren, Leanne, and Lori."
Meu nome é Márcia, mãe de dois filhos nascidos em meio hospitalar. Partos diferentes, emoções diferentes. O primeiro cesariana com todos, ou quase todos os procedimentos. O outro um parto vaginal, tranquilo, respeitado, acompanhado por uma querida doula. Tornei-me doula porque sinto que esse é o meu papel, o meu propósito. Apoiar e informar os casais para que possam tomar decisões conscientes para um momento tão especial. Sou também especialista em Medicina Tradicional Chinesa, focando-me no estudo da pediatria e alargando agora os meus conhecimentos na gravidez.